the upside chewable

Gummies
100–200 mg
Dissolvable tablets
300 mg
Capsules
500 mg

MORE NUTRIENT LOAD, MORE EFFICACY. IN THE WAYS THAT MATTER.

No melatonin, no dependency

Formulated by experts across pharmacology, dietetics, nutrition and toxicology

Multi-pathway synergistic formulation

Reverses the activation.

The 3AM wake-up is not insomnia, but a stress response. 3AM Rescue works on the root cause of cortisol, alertness & temperature to help you fall asleep.

Calms without sedating.

We don't force it. 3AM Rescue reduces the activation that's keeping you awake so sleep comes naturally.

Works in minutes.

The chewable starts absorbing in your mouth before it reaches your stomach, so you start drifting off within 15-20 minutes

Leaves nothing behind.

Non-habit forming, no grogginess, no rebound effect. Whether you take it tonight or don't take it tomorrow, your body responds the same way either time.

the evidence

Glycine 3g

Lowers core body temperature slightly - the exact physiological signal your brain uses to initiate deep sleep.

🔗
Yamadera, Wataru, et al.
Sleep and Biological Rhythms, vol. 5, no. 2, 2007, pp. 126-131
Bannai, Makoto, et al.
Frontiers in Neurology, vol. 3, 2012, article 61
Night
Get Sleep
30mins
sooner
Day
33%
less fatigue felt in day time

Passiflora Incarnata L. 200mg

Increases GABA activity in the brain - the calming neurotransmitter that tells your nervous system it's safe to stop being vigilant.

🔗
Improved
Stress resilience
Reduced
Sleep disturbance
Reduced
Inner restlessness
Reduced
Exhaustion

L-Theanine 100mg

Promotes alpha brain wave activity - the same relaxed-but-alert state you're in just before sleep, or right after a good meditation.

🔗
Bulman, Amanda, et al.
Sleep Medicine Reviews, vol. 81, 2025, article 102076
Improved
Sleep onset
Improved
Sleep quality
Improved
Daytime functioning
Glycine

Glycine 3g

Lowers core body temperature slightly - the exact physiological signal your brain uses to initiate deep sleep.

🔗
Yamadera, Wataru, et al.
Sleep and Biological Rhythms, vol. 5, no. 2, 2007, pp. 126-131
Bannai, Makoto, et al.
Frontiers in Neurology, vol. 3, 2012, article 61
Night
Get Sleep
30mins
sooner
Day
33%
less fatigue felt in day time
Passiflora Incarnata L.

Passiflora Incarnata L. 200mg

Increases GABA activity in the brain - the calming neurotransmitter that tells your nervous system it's safe to stop being vigilant.

🔗
Improved
Stress resilience
Improved
Sleep disturbance
Improved
Inner restlessness
Improved
Exhaustion
L-Theanine

L-Theanine 100mg

Promotes alpha brain wave activity - the same relaxed-but-alert state you're in just before sleep, or right after a good meditation.

🔗
Bulman, Amanda, et al.
Sleep Medicine Reviews, vol. 81, 2025, article 102076
Improved
Sleep onset
Improved
Sleep quality
Improved
Daytime functioning
SCIENCE, EXPLAINED.

FROM BASICS TO BIOLOGY TO RESEARCH

THE BASICS
Your mind stops treating 3am like the start of the day.
The physical alertness - the heart rate, the tension - settles back down.
You stop lying awake and start drifting back.
The morning arrives without the hollowness of a broken night.

It triggers the temperature drop.

Glycine works on the brain's internal clock, supporting the peripheral vasodilation that lowers core body temperature, the physical signal that tells your body sleep is still happening. When you wake at 3am, that signal has been interrupted. Glycine helps restore it.

It quiets the alert system.

Passionflower works through GABA receptors, the brain's primary inhibitory pathway, to reduce the neurological activation that keeps you awake after waking. It brings down the signal that's telling your nervous system to stay alert.

It reduces the cortisol spike.

L-Theanine measurably reduces cortisol and promotes alpha wave activity, the brain state associated with calm, relaxed alertness. At 3am, cortisol rises earlier than it should. L-Theanine addresses that spike directly, reducing the physiological activation that makes getting back to sleep so difficult.

It works without leaving a trace.

None of the three ingredients sedate, suppress sleep architecture or create dependency. There's no morning grogginess as a consequence of taking it, no adaptation over time and no rebound effect if you stop.

Glycine and sleep thermoregulation.

Glycine acts on NMDA receptors in the suprachiasmatic nucleus, triggering peripheral vasodilation and core body temperature reduction, the same thermoregulatory pathway that initiates sleep onset. Polysomnographic-confirmed studies show glycine at 3g reduces nighttime waking and shortens re-entry into slow-wave sleep.

Passionflower and GABAergic activity.

Passiflora incarnata standardised to 3% flavonoid glycosides modulates GABA-A receptors via its own binding site, increasing inhibitory tone without the tolerance or dependency associated with benzodiazepines.

L-Theanine and cortisol reduction.

L-Theanine reduces cortisol measurably and promotes alpha wave induction, the transitional brain state between alert and asleep. L-Theanine has been shown to reduce physiological stress markers and improve next-day functioning by approximately 31%, reflecting improved sleep quality, not just sedation.

The formulation logic.

The three ingredients work across three distinct pathways simultaneously: thermoregulation (Glycine), inhibitory tone (Passionflower) and cortisol reduction (L-Theanine). The 3am wake-up is rarely caused by one thing alone, it's a convergence of signals that keep the body in alert state. 3AM Rescue addresses all three at once.

WHICH ONE DO YOU NEED?

OR
Your mind is still running from the day and won't switch off
You fall asleep fine but wake up through the night
Daytime stress is spilling into the evening and disrupting wind-down
Disrupted sleep has become frequent, not occasional - this is for the pattern, not a single night

3am rescue is if or when you wake up
Quiet nights is to stop waking up

INGREDIENT GLOSSARY

Tap on the ingredient to see full information

Glycine

A simple amino acid, abundant in the human body.

DIETARY SOURCES:
Collagen rich sources of food such as meat, and from legumes, soybeans and seeds.

WHAT IT DOES
Lowers core body temperature slightly, which is the exact physiological signal your brain uses to initiate deep sleep.

WHAT IT FEELS LIKE
You stop fighting sleep and the shift from awake to asleep feels less like a drop and more like a slide.

Passionflower extract

Extracted from the aerial parts of Passiflora incarnata, a climbing vine with a long history of traditional use for anxiety and sleeplessness. A medicinal botanical with no food equivalent.

WHAT IT DOES
Increases GABA activity in the brain, which is the calming neurotransmitter that tells your nervous system it's safe to stop being vigilant.

WHAT IT FEELS LIKE
The 3AM spiral slows and thoughts stop arriving with the same urgency. There's space between them.

L-Theanine

An amino acid found almost exclusively in tea leaves. If you want it from your cup, drink a strong steep of green or white tea.

WHAT IT DOES
Promotes alpha brain wave activity, the same relaxed-but-alert state you're in just before sleep or right after a good meditation session.

WHAT IT FEELS LIKE
Alert but not wired, calm but not drowsy. The edges of the day start to soften without your focus going with them.

Questions worth asking

How is this different from a regular sleep supplement?


Most sleep supplements are designed to help you fall asleep - they're taken before bed and work on sleep onset. 3AM Rescue is built for a different problem entirely: waking mid-night and not being able to return to sleep. The ingredients, the doses and the timing are all specific to that moment. It's not a general sleep aid. It's a targeted intervention for one very specific experience.

It is. Cortisol, your body's primary stress hormone, follows a natural daily rhythm, beginning to rise in the early hours to prepare you for waking. Under stress, that rise turns into a middle-of-the-night spike, activating the nervous system before the night is actually over. 3am sits right in that window. It's not random, and it's not a coincidence that so many people report waking at the same time.

Because your stress response has already activated. The moment cortisol rises, your brain and body wake up, running through the day, anticipating what's coming, solving problems that don't need solving at 3am. It's the same system that gets you ready for the day, just firing at the wrong time.


Calm you down, and that's deliberate. 3AM Rescue doesn't sedate or force unconsciousness. It reduces the activation that's keeping you awake, so sleep becomes available again on its own. 

The chewable format begins absorbing in the mouth before it reaches the stomach, which speeds onset. Most people find the activation starts to reduce within 20 to 30 minutes. The goal is that by the time it's fully absorbed, the cortisol spike has come down enough for sleep to become available again.

At the moment of waking. It's designed for that specific moment, not as a preventative. Keep it on your bedside table so it's there immediately when you need it. Getting up to find it adds time and wakefulness you don't want.


No. None of the three ingredients sedate or suppress sleep architecture. They work by reducing activation rather than forcing unconsciousness, so there's no grogginess as a consequence. The goal is natural sleep resumption, and a morning that reflects that.

Yes. 3AM Rescue is specifically built for the staying-asleep problem. Falling asleep is a different mechanism to returning to sleep after waking, and the ingredients here are targeted at exactly that. But if this is happening persistently, it may be worth looking at Quiet Nights or Total Stress Support.

3AM Rescue addresses the physiological side of waking - the cortisol spike, the neural activation, the temperature disruption. If sleep still doesn't return, the cause may be environmental (light, noise, room temperature) or something that needs more consistent support over time.

Yes, though it's worth understanding what's driving it. If the pattern is stress-related activation - the cortisol rhythm described above - 3AM Rescue is a great SOS, but maybe you need a Quiet Nights to solve it permanently. If it's something else, like sleep apnea or a medical condition, it won't resolve the underlying cause.

Will this help? 
It won't address the bathroom waking itself, that's a separate issue. But the part that 3AM Rescue is built for is exactly what happens next: lying awake after waking, mind already running, unable to return to sleep. If that's the experience once you're back in bed, it's relevant.


It depends on how much sleep you still need. If you have two or more hours before you need to be up, taking it is reasonable. The ingredients don't leave a residue that would make waking harder. If you're within an hour of your alarm, the return is lower and you may be better off getting up rather than chasing the last fragments of sleep.

For when you are wide awake in the middle of the night